Tf-cmte130322 201..207
نویسندگان
چکیده
Background: Clinical supervision has gained wide recognition in recent years as an essential component of a practitioner’s continuing professional development. However, confusion exists in professional literature regarding the most effective models, styles, processes and methods of clinical supervision. Aim: This article outlines the elements required to establish and sustain an effective clinical supervision arrangement for health professionals, based on current evidence and the author’s expert opinion. Conclusion: A set of practical strategies are proposed to assist practitioners to establish an ongoing, effective clinical supervision partnership.
منابع مشابه
Effective treatment of metastatic MDA-MB-435 human estrogen-independent breast carcinomas with a targeted cytotoxic analogue of luteinizing hormone-releasing hormone AN-207.
A highly potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201), was linked to [D-Lys6]luteinizing hormone-releasing hormone (LH-RH) to form a cytotoxic analogue, AN-207, that can be targeted to LH-RH receptors. The effects of AN-207 were investigated in MDA-MB-435 human estrogen-independent breast carcinomas, which express LH-RH receptors. In experiment 1, nude mice bearing orthotop...
متن کاملSelective induction of apoptosis by the cytotoxic analog AN-207 in cells expressing recombinant receptor for luteinizing hormone-releasing hormone.
The selectivity of ligands specific for certain cells can be used to preferentially target chemotherapeutic compounds to neoplastic cells. Human breast, ovarian, endometrial, and prostatic cancers express receptors that can mediate the delivery of targeted cytotoxic compounds to neoplastic cells. Recently, a potent derivative of 2-pyrrolinodoxorubicin (AN-201) conjugated to [D-Lys6] luteinizing...
متن کاملTargeted cytotoxic analogs of luteinizing hormone-releasing hormone: a reply.
We read with great interest the Highlight Review by Dr C GruÈ ndker entitled `Cytotoxic luteinizing hormonereleasing hormone conjugates and their use in gynecological cancer therapy' in the European Journal of Endocrinology (1). This excellent article provides a detailed description of recent developments in the field of targeted chemotherapy based on luteinizing hormone-releasing hormone (LH-R...
متن کاملRecovery of pituitary function after treatment with a targeted cytotoxic analog of luteinizing hormone-releasing hormone (targeted chemotherapyypituitary hormonesygrowth hormoneythyrotropinyselective damage)
Recently, we developed a targeted cytotoxic analog AN-207 of luteinizing hormone-releasing hormone (LH-RH), consisting of an intensely potent derivative of doxorubicin, 2-pyrrolinodoxorubicin (AN-201) conjugated to carrier agonist [D-Lys6]LH-RH. In this study, we investigated the effects of cytotoxic analog AN-207, designed for targeted chemotherapy and radical AN-201 on pituitary function in r...
متن کاملReceptors for luteinizing hormone releasing hormone expressed on human renal cell carcinomas can be used for targeted chemotherapy with cytotoxic luteinizing hormone releasing hormone analogues.
PURPOSE To determine the expression of luteinizing hormone releasing hormone (LHRH) receptors in specimens and cell lines of human renal cell carcinoma (RCC) and to evaluate the antitumor efficacy of targeted therapy with a cytotoxic analogue of LHRH, AN-207, in vivo. AN-207, consisting of [D-Lys(6)] LHRH linked to a cytotoxic radical, 2-pyrrolinodoxorubicin (AN-201), binds with high affinity t...
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